PEBP1
Gene Ontology Biological Process
- MAPK cascade [IDA]
- aging [IEP]
- brain development [IEP]
- eating behavior [IEP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of acetylcholine metabolic process [IDA]
- positive regulation of cAMP-mediated signaling [IMP]
- positive regulation of mitosis [IMP]
- regulation of neurotransmitter levels [IDA]
- regulation of the force of heart contraction [IDA]
- response to activity [IEP]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to ethanol [IEP]
- response to heat [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IEP]
- response to toxic substance [IEP]
- response to wounding [IEP]
- sperm capacitation [ISO]
- spermatid development [IEP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- apical part of cell [IDA]
- axon terminus [IDA]
- cell surface [IDA, ISO]
- cytoplasm [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- rough endoplasmic reticulum [IDA]
- synaptic vesicle [IDA]
MAP3K7
Gene Ontology Biological Process
- I-kappaB phosphorylation [IGI]
- MAPK cascade [IDA]
- activation of MAPK activity [IDA]
- angiogenesis [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of necroptotic process [IMP]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of ripoptosome assembly involved in necroptotic process [IGI]
- neural tube formation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of JNK cascade [IGI]
- protein phosphorylation [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.
The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1. RKIP inhibits the phosphorylation of MAP/extracellular signal-regulated kinase 1 (MEK1) by Raf-1 by disrupting the interaction between these two kinases. We show here that RKIP also antagonizes the signal transduction pathways that mediate the activation of the transcription ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID