BAIT
SLC2A1
DYT17, DYT18, DYT9, EIG12, GLUT, GLUT-1, GLUT1, GLUT1DS, HTLVR, PED
solute carrier family 2 (facilitated glucose transporter), member 1
GO Process (11)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- L-ascorbic acid metabolic process [TAS]
- carbohydrate metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glucose transport [IDA, TAS]
- hexose transport [TAS]
- protein complex assembly [IDA]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLSCR1
MMTRA1B
phospholipid scramblase 1
GO Process (14)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- acute-phase response [ISS]
- apoptotic process [IDA]
- defense response to virus [IMP]
- negative regulation of viral genome replication [IMP]
- phosphatidylserine biosynthetic process [ISS]
- phospholipid scrambling [IDA]
- platelet activation [NAS]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of innate immune response [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [ISS]
- regulation of mast cell activation [ISS]
- response to interferon-beta [IMP]
Gene Ontology Molecular Function- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.992655548 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.992655548, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID