BAIT
TDGF1
CR, CRGF, CRIPTO
teratocarcinoma-derived growth factor 1
GO Process (22)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- anterior/posterior axis specification, embryo [ISS]
- cell differentiation [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [IDA]
- cellular response to interferon-gamma [IDA]
- cellular response to interleukin-6 [IDA]
- cellular response to tumor necrosis factor [IDA]
- embryo development [TAS]
- epidermal growth factor receptor signaling pathway [IDA]
- heart development [IDA]
- mammary gland development [TAS]
- morphogenesis of a branching structure [TAS]
- negative regulation of apoptotic process [IDA]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA, TAS]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FBXO45
Fbx45
F-box protein 45
GO Process (4)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999489139 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.999489139, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID