BAIT
PEX19
D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1, OK/SW-cl.22
peroxisomal biogenesis factor 19
GO Process (11)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- chaperone-mediated protein folding [IDA]
- chaperone-mediated protein transport [IDA]
- establishment of protein localization to peroxisome [IMP]
- negative regulation of lipid binding [IDA]
- peroxisome fission [IMP]
- peroxisome membrane biogenesis [IDA]
- peroxisome organization [IMP, NAS]
- protein import into peroxisome membrane [IDA]
- protein stabilization [IDA]
- protein targeting to peroxisome [IDA, IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC27A1
ACSVL5, FATP, FATP1
solute carrier family 27 (fatty acid transporter), member 1
GO Process (12)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- cardiolipin biosynthetic process [IMP]
- cellular lipid metabolic process [TAS]
- long-chain fatty acid transport [TAS]
- negative regulation of phospholipid biosynthetic process [IMP]
- phosphatidic acid biosynthetic process [IMP]
- phosphatidylcholine biosynthetic process [IMP]
- phosphatidylethanolamine biosynthetic process [IMP]
- phosphatidylglycerol biosynthetic process [IMP]
- phosphatidylinositol biosynthetic process [IMP]
- phosphatidylserine biosynthetic process [IMP]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.956358393 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.956358393, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID