HMOX2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TAP1
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytosol to ER transport [IMP]
- intracellular transport of viral protein in host cell [IMP]
- peptide transport [IMP]
- transmembrane transport [IBA]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class Ib protein binding [IPI]
- TAP1 binding [ISS]
- TAP2 binding [IPI]
- peptide antigen binding [NAS]
- peptide transporter activity [IGI, IMP]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class Ib protein binding [IPI]
- TAP1 binding [ISS]
- TAP2 binding [IPI]
- peptide antigen binding [NAS]
- peptide transporter activity [IGI, IMP]
- protein binding [IPI]
- protein homodimerization activity [ISS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.990181257 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.990181257, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TAP1 HMOX2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID