BAIT
NRG1
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
neuregulin 1
GO Process (33)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of transmembrane receptor protein tyrosine kinase activity [IDA, NAS]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle cell myoblast differentiation [IDA]
- cell communication [TAS]
- cell proliferation [IDA]
- cellular protein complex disassembly [IGI]
- endocardial cell differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mammary gland development [TAS]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of secretion [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neural crest cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of striated muscle cell differentiation [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular cardiac muscle cell differentiation [IDA]
- ventricular trabecula myocardium morphogenesis [IDA]
- wound healing [IDA, TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
MGST3
GST-III, RP11-466F5.1
microsomal glutathione S-transferase 3
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.854186819 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.854186819, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID