BAIT
RYR2
ARVC2, ARVD2, RYR-2, RyR, VTSIP, RP4-626J7.1
ryanodine receptor 2 (cardiac)
GO Process (35)
GO Function (13)
GO Component (9)
Gene Ontology Biological Process
- Purkinje myocyte to ventricular cardiac muscle cell signaling [ISS]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- calcium-mediated signaling [ISS]
- calcium-mediated signaling using intracellular calcium source [IDA]
- cardiac muscle contraction [IMP]
- cardiac muscle hypertrophy [ISS]
- cell communication by electrical coupling involved in cardiac conduction [IC]
- cellular calcium ion homeostasis [ISS]
- cellular response to caffeine [IDA, ISS]
- cellular response to epinephrine stimulus [TAS]
- cytosolic calcium ion homeostasis [ISS]
- detection of calcium ion [IDA]
- embryonic heart tube morphogenesis [ISS]
- establishment of protein localization to endoplasmic reticulum [IDA]
- ion transmembrane transport [TAS]
- left ventricular cardiac muscle tissue morphogenesis [ISS]
- positive regulation of calcium-transporting ATPase activity [IDA]
- positive regulation of heart rate [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [ISS]
- positive regulation of sequestering of calcium ion [IDA]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, ISS]
- regulation of heart rate [IMP]
- release of sequestered calcium ion into cytosol [IDA, ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP, ISS]
- response to caffeine [IDA]
- response to hypoxia [ISS]
- response to muscle stretch [IMP]
- response to redox state [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
- type B pancreatic cell apoptotic process [IMP]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
CACNA1D
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD
calcium channel, voltage-dependent, L type, alpha 1D subunit
GO Process (17)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISS]
- axon guidance [TAS]
- calcium ion import [IDA]
- calcium ion transmembrane transport [ISS]
- calcium ion transport [IDA]
- energy reserve metabolic process [TAS]
- membrane depolarization during action potential [IBA]
- membrane depolarization during cardiac muscle cell action potential [IC]
- membrane repolarization during SA node cell action potential [IMP]
- positive regulation of calcium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of insulin secretion [TAS]
- regulation of potassium ion transmembrane transport [ISS]
- regulation of potassium ion transmembrane transporter activity [ISS]
- sensory perception of sound [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- alpha-actinin binding [IPI]
- ankyrin binding [ISS]
- high voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity involved SA node cell action potential [IMP]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
- alpha-actinin binding [IPI]
- ankyrin binding [ISS]
- high voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity involved SA node cell action potential [IMP]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.
The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR). We used super-resolution and FRET microscopy to investigate the proximity and functional coupling among Cav1.3/Cav1.2, RyR2, and KCa3.1 potassium channels that contribute to the sAHP. dSTORM and FRET imaging shows that Cav1.3, RyR2, ... [more]
Cell Rep Dec. 27, 2018; 28(9);2427-2442.e6 [Pubmed: 31461656]
Throughput
- Low Throughput
Curated By
- BioGRID