BAIT
CACNA1D
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD
calcium channel, voltage-dependent, L type, alpha 1D subunit
GO Process (17)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISS]
- axon guidance [TAS]
- calcium ion import [IDA]
- calcium ion transmembrane transport [ISS]
- calcium ion transport [IDA]
- energy reserve metabolic process [TAS]
- membrane depolarization during action potential [IBA]
- membrane depolarization during cardiac muscle cell action potential [IC]
- membrane repolarization during SA node cell action potential [IMP]
- positive regulation of calcium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of insulin secretion [TAS]
- regulation of potassium ion transmembrane transport [ISS]
- regulation of potassium ion transmembrane transporter activity [ISS]
- sensory perception of sound [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- alpha-actinin binding [IPI]
- ankyrin binding [ISS]
- high voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity involved SA node cell action potential [IMP]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
- alpha-actinin binding [IPI]
- ankyrin binding [ISS]
- high voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity involved SA node cell action potential [IMP]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
Gene Ontology Cellular Component
Homo sapiens
PREY
JPH4
JP4, JPHL1
junctophilin 4
GO Process (2)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.
The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR). We used super-resolution and FRET microscopy to investigate the proximity and functional coupling among Cav1.3/Cav1.2, RyR2, and KCa3.1 potassium channels that contribute to the sAHP. dSTORM and FRET imaging shows that Cav1.3, RyR2, ... [more]
Cell Rep Dec. 27, 2018; 28(9);2427-2442.e6 [Pubmed: 31461656]
Throughput
- Low Throughput
Curated By
- BioGRID