BAIT
TRIB2
C5FW, GS3955, TRB2
tribbles pseudokinase 2
GO Process (6)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of fat cell differentiation [ISS]
- negative regulation of interleukin-10 biosynthetic process [IMP]
- negative regulation of protein kinase activity [NAS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [ISS]
- regulation of MAP kinase activity [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PPP1R12A
M130, MBS, MYPT1
protein phosphatase 1, regulatory subunit 12A
GO Process (10)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- centrosome organization [IMP]
- mitotic cell cycle [TAS]
- mitotic nuclear division [IMP]
- negative regulation of catalytic activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein dephosphorylation [IMP]
- regulation of cell adhesion [IDA]
- regulation of myosin-light-chain-phosphatase activity [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.
The regulation of homeostasis in the Ubiquitin (Ub) proteasome system (UPS) is likely to be important for the development of liver cancer. Tribbles homolog 2 (TRIB2) is known to affect Ub E3 ligases (E3s) in liver cancer. However, whether TRIB2 regulates the UPS in other ways and the relevant mechanisms are still unknown. Here, we reveal that TRIB2 decreased Ub ... [more]
Cell Death Dis Dec. 07, 2020; 12(1);42 [Pubmed: 33414446]
Throughput
- Low Throughput
Curated By
- BioGRID