BAIT
SPRTN
C1orf124, DDDL1880, DVC1, PRO4323, Spartan, dJ876B10.3, RP5-876B10.3
SprT-like N-terminal domain
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADAR
ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136, RP11-61L14.5
adenosine deaminase, RNA-specific
GO Process (15)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, TAS]
- base conversion or substitution editing [IDA]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA modification [TAS]
- miRNA loading onto RISC involved in gene silencing by miRNA [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA, IMP]
- positive regulation of viral genome replication [IDA, IMP]
- pre-miRNA processing [IDA]
- protein export from nucleus [IDA]
- protein import into nucleus [IDA]
- response to interferon-alpha [IDA]
- response to virus [IMP]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.
DNA-protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. USP11 deubiquitinase participates in DNA repair, but the role of USP11 in DPC repair is not known. SPRTN is a replication-coupled DNA-dependent metalloprotease that cleaves proteins cross-linked to DNA to promote DPC repair. SPRTN function is tightly regulated by a monoubiquitin ... [more]
J Biol Chem Feb. 11, 2021; 296();100396 [Pubmed: 33567341]
Throughput
- Low Throughput
Curated By
- BioGRID