SPRTN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOD
Gene Ontology Biological Process
- aging [NAS]
- angiogenesis [NAS]
- brain development [ISS]
- glucose metabolic process [IDA]
- lipid metabolic process [IDA]
- lipid transport [NAS]
- negative regulation of T cell migration [IDA]
- negative regulation of cytokine production involved in inflammatory response [IDA]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of lipoprotein lipid oxidation [IDA]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IMP]
- peripheral nervous system axon regeneration [ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to reactive oxygen species [IDA]
- tissue regeneration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.
DNA-protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. USP11 deubiquitinase participates in DNA repair, but the role of USP11 in DPC repair is not known. SPRTN is a replication-coupled DNA-dependent metalloprotease that cleaves proteins cross-linked to DNA to promote DPC repair. SPRTN function is tightly regulated by a monoubiquitin ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SPRTN APOD | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9987 | BioGRID | 3183096 |
Curated By
- BioGRID