BAIT
SPRTN
C1orf124, DDDL1880, DVC1, PRO4323, Spartan, dJ876B10.3, RP5-876B10.3
SprT-like N-terminal domain
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NDUFA13
B16.6, CDA016, GRIM-19, GRIM19, CGI-39
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
GO Process (14)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- apoptotic signaling pathway [IDA]
- cellular metabolic process [TAS]
- cellular response to interferon-beta [IDA]
- cellular response to retinoic acid [IDA]
- negative regulation of cell growth [IDA, IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI]
- positive regulation of peptidase activity [IC]
- positive regulation of protein catabolic process [IGI]
- protein import into mitochondrial inner membrane [IDA]
- reactive oxygen species metabolic process [IMP]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.
DNA-protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. USP11 deubiquitinase participates in DNA repair, but the role of USP11 in DPC repair is not known. SPRTN is a replication-coupled DNA-dependent metalloprotease that cleaves proteins cross-linked to DNA to promote DPC repair. SPRTN function is tightly regulated by a monoubiquitin ... [more]
J Biol Chem Feb. 11, 2021; 296();100396 [Pubmed: 33567341]
Throughput
- Low Throughput
Curated By
- BioGRID