BAIT
INO80
INO80A, INOC1, hINO80
INO80 complex subunit
GO Process (14)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA]
- UV-damage excision repair [IMP]
- cellular response to UV [IMP]
- cellular response to ionizing radiation [IMP]
- chromatin remodeling [IDA]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- mitotic sister chromatid segregation [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of nuclear cell cycle DNA replication [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- spindle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRMT5
HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs
protein arginine methyltransferase 5
GO Process (13)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cell proliferation [TAS]
- circadian regulation of gene expression [ISS]
- endothelial cell activation [IMP]
- gene expression [TAS]
- histone H4-R3 methylation [ISS, NAS]
- ncRNA metabolic process [TAS]
- peptidyl-arginine N-methylation [IDA]
- peptidyl-arginine methylation [IMP]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IMP]
- regulation of mitosis [TAS]
- regulation of transcription, DNA-templated [IBA]
- spliceosomal snRNP assembly [IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication.
The INO80 chromatin remodeling complex has roles in many essential cellular processes, including DNA replication. However, the mechanisms that regulate INO80 in these processes remain largely unknown. We previously reported that the stability of Ino80, the catalytic ATPase subunit of INO80, is regulated by the ubiquitin proteasome system and that BRCA1-associated protein-1 (BAP1), a nuclear deubiquitinase with tumor suppressor activity, ... [more]
Mol Cells Feb. 28, 2021; 44(2);101-115 [Pubmed: 33658435]
Throughput
- Low Throughput
Curated By
- BioGRID