PRKACA
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- cellular response to parathyroid hormone stimulus [IMP]
- mesoderm formation [IGI]
- negative regulation of meiotic cell cycle [ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- neural tube closure [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of protein export from nucleus [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of cellular respiration [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- regulation of protein processing [IGI]
- regulation of synaptic transmission [IMP]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of tight junction assembly [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- AMP-activated protein kinase complex [ISO]
- Golgi apparatus [ISO]
- cAMP-dependent protein kinase complex [ISO]
- centrosome [ISO]
- ciliary base [IDA]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrion [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sperm midpiece [ISO]
CHRNA4
Gene Ontology Biological Process
- B cell activation [IMP]
- DNA repair [ISO]
- action potential [IMP]
- behavioral response to nicotine [IMP, ISO]
- calcium ion transport [IGI]
- cation transmembrane transport [IGI, ISO]
- cation transport [ISO]
- cognition [ISO]
- exploration behavior [IMP]
- ion transmembrane transport [IDA]
- locomotory behavior [IMP]
- membrane depolarization [IGI, IMP]
- neurological system process [IMP, ISO]
- positive regulation of dopamine secretion [ISO]
- protein heterooligomerization [ISO]
- regulation of dopamine secretion [IMP]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of membrane potential [IGI]
- respiratory gaseous exchange [IMP]
- response to hypoxia [ISO]
- response to nicotine [IGI, IMP, ISO]
- response to oxidative stress [ISO]
- sensory perception of pain [IMP, TAS]
- signal transduction [ISO]
- synaptic transmission, cholinergic [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo.
Activation of nicotinic acetylcholine receptors containing ?4 and ?2 subunits (?4/?2* nAChRs) in the mammalian brain is necessary for nicotine reinforcement and addiction. We previously identified interactions between ?4/?2* nAChRs and calcium/calmodulin-dependent protein kinase II (CaMKII) in mouse and human brain tissue. Following co-expression of ?4/?2 nAChR subunits with CaMKII in HEK cells, mass spectrometry identified 8 phosphorylation sites in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID