SH3BP4
Gene Ontology Biological Process
- amino acid import [IMP]
- cellular response to amino acid stimulus [IMP]
- negative regulation of GTPase activity [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell proliferation [IMP]
- positive regulation of autophagy [IMP]
- protein localization to lysosome [IMP]
- regulation of catalytic activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SFN
Gene Ontology Biological Process
- apoptotic process [TAS]
- establishment of skin barrier [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- membrane organization [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of protein kinase activity [TAS]
- negative regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of epidermal cell differentiation [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of epidermal cell division [ISS]
- release of cytochrome c from mitochondria [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SH3BP4 promotes neuropilin-1 and ?5-integrin endocytosis and is inhibited by Akt.
Cells probe their surrounding matrix for attachment sites via integrins that are internalized by endocytosis. We find that SH3BP4 regulates integrin surface expression in a signaling-dependent manner via clathrin-coated pits (CCPs). Dephosphorylated SH3BP4 at S246 is efficiently recruited to CCPs, while upon Akt phosphorylation, SH3BP4 is sequestered by 14-3-3 adaptors and excluded from CCPs. In the absence of Akt activity, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SFN SH3BP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 244966 |
Curated By
- BioGRID