BAIT

FBXO21

F-box protein 21
GO Process (0)
GO Function (0)
GO Component (0)
Rattus norvegicus
PREY

MYOF

Fer1l3, RGD1564216
myoferlin
Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy.

Lin Z, Miao J, Zhang T, He M, Wang Z, Feng X, Bai L

Osteoarthritis (OA) is a heterogeneous disease that is extremely hard to cure owing to its complex regulation network of pathogenesis, especially cartilage degeneration. FBXO21 is a subunit of ubiquitin E3 ligases that degrades P-glycoprotein and EID1 by ubiquitination and activates the JNK and p38 pathways; however, its role in OA remains unknown. Here, the main objective of this study was ... [more]

Aging Cell Dec. 01, 2020; 20(2);e13306 [Pubmed: 33450132]

Throughput

  • High Throughput

Curated By

  • BioGRID