BAIT

MECP2

1500041B07Rik, D630021H01Rik, Mbd5, WBP10, RP23-252M19.8
methyl CpG binding protein 2
GO Process (58)
GO Function (17)
GO Component (9)

Gene Ontology Biological Process

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.

Li R, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, Li H, Zhao X, Keles S, Wang Z, Chang Q

Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, the molecular function of MeCP2 is not fully understood. Here we report a systematic identification of MeCP2-interacting proteins in the mouse brain. In addition to transcription regulators, we found that MeCP2 physically interacts with several modulators of RNA ... [more]

PLoS Genet Dec. 01, 2015; 12(6);e1006129 [Pubmed: 27352031]

Throughput

  • Low Throughput

Curated By

  • BioGRID