MECP2
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- behavioral fear response [IMP]
- brain development [IMP]
- cardiolipin metabolic process [IMP]
- catecholamine secretion [IMP]
- cellular biogenic amine metabolic process [IMP]
- cerebellum development [IMP]
- chromatin silencing [IMP]
- dendrite development [IMP]
- embryo development [IMP]
- glucocorticoid metabolic process [IMP]
- glutamine metabolic process [IMP]
- histone acetylation [IMP]
- histone methylation [IMP]
- inositol metabolic process [IMP]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- mitochondrial electron transport, ubiquinol to cytochrome c [IMP]
- multicellular organismal response to stress [IMP]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of histone acetylation [IMP]
- negative regulation of histone methylation [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- neurological system process involved in regulation of systemic arterial blood pressure [IMP]
- neuromuscular process [IMP]
- neuromuscular process controlling posture [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- pathogenesis [IMP]
- phosphatidylcholine metabolic process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of synapse assembly [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IMP]
- proprioception [IMP]
- protein localization [IMP]
- regulation of DNA methylation [ISO]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of gene expression [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IMP]
- regulation of synaptic plasticity [IMP]
- regulation of transcription, DNA-templated [IMP]
- respiratory gaseous exchange [IMP]
- response to hypoxia [IMP]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP]
- ventricular system development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- double-stranded methylated DNA binding [IDA, ISO, ISS]
- enzyme binding [ISO]
- four-way junction DNA binding [ISO]
- histone deacetylase binding [ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- siRNA binding [IDA]
- transcription factor binding [IPI]
- unmethylated CpG binding [ISO]
- DNA binding [IDA]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- double-stranded methylated DNA binding [IDA, ISO, ISS]
- enzyme binding [ISO]
- four-way junction DNA binding [ISO]
- histone deacetylase binding [ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- siRNA binding [IDA]
- transcription factor binding [IPI]
- unmethylated CpG binding [ISO]
Gene Ontology Cellular Component
FUS
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.
Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, the molecular function of MeCP2 is not fully understood. Here we report a systematic identification of MeCP2-interacting proteins in the mouse brain. In addition to transcription regulators, we found that MeCP2 physically interacts with several modulators of RNA ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MECP2 FUS | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FUS MECP2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID