BAIT
MECP2
1500041B07Rik, D630021H01Rik, Mbd5, WBP10, RP23-252M19.8
methyl CpG binding protein 2
GO Process (58)
GO Function (17)
GO Component (9)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- behavioral fear response [IMP]
- brain development [IMP]
- cardiolipin metabolic process [IMP]
- catecholamine secretion [IMP]
- cellular biogenic amine metabolic process [IMP]
- cerebellum development [IMP]
- chromatin silencing [IMP]
- dendrite development [IMP]
- embryo development [IMP]
- glucocorticoid metabolic process [IMP]
- glutamine metabolic process [IMP]
- histone acetylation [IMP]
- histone methylation [IMP]
- inositol metabolic process [IMP]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- mitochondrial electron transport, ubiquinol to cytochrome c [IMP]
- multicellular organismal response to stress [IMP]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of histone acetylation [IMP]
- negative regulation of histone methylation [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- neurological system process involved in regulation of systemic arterial blood pressure [IMP]
- neuromuscular process [IMP]
- neuromuscular process controlling posture [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- pathogenesis [IMP]
- phosphatidylcholine metabolic process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of synapse assembly [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IMP]
- proprioception [IMP]
- protein localization [IMP]
- regulation of DNA methylation [ISO]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of gene expression [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IMP]
- regulation of synaptic plasticity [IMP]
- regulation of transcription, DNA-templated [IMP]
- respiratory gaseous exchange [IMP]
- response to hypoxia [IMP]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP]
- ventricular system development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- double-stranded methylated DNA binding [IDA, ISO, ISS]
- enzyme binding [ISO]
- four-way junction DNA binding [ISO]
- histone deacetylase binding [ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- siRNA binding [IDA]
- transcription factor binding [IPI]
- unmethylated CpG binding [ISO]
- DNA binding [IDA]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- double-stranded methylated DNA binding [IDA, ISO, ISS]
- enzyme binding [ISO]
- four-way junction DNA binding [ISO]
- histone deacetylase binding [ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- siRNA binding [IDA]
- transcription factor binding [IPI]
- unmethylated CpG binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
GRIA2
GluA2, GluR-B, Glur-2, Glur2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
GO Process (10)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- establishment of protein localization [ISO]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- positive regulation of synaptic transmission [ISO]
- protein tetramerization [ISO]
- receptor internalization [ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- synaptic transmission [IDA, ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- cell surface [ISO]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [ISO]
- perikaryon [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, IDA]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [ISO]
- terminal bouton [ISO]
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.
Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, the molecular function of MeCP2 is not fully understood. Here we report a systematic identification of MeCP2-interacting proteins in the mouse brain. In addition to transcription regulators, we found that MeCP2 physically interacts with several modulators of RNA ... [more]
PLoS Genet Dec. 01, 2015; 12(6);e1006129 [Pubmed: 27352031]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID