PPIF
Gene Ontology Biological Process
- apoptotic mitochondrial changes [IBA, ISO]
- cellular response to arsenic-containing substance [ISO, ISS]
- cellular response to calcium ion [ISO, ISS]
- cellular response to hydrogen peroxide [ISO, ISS]
- necroptotic process [ISO]
- negative regulation of ATPase activity [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of oxidative phosphorylation [ISO, ISS]
- negative regulation of oxidative phosphorylation uncoupler activity [ISO, ISS]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- positive regulation of release of cytochrome c from mitochondria [ISO, ISS]
- regulation of apoptotic process [IDA]
- regulation of mitochondrial membrane permeability [IDA, ISO]
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [IBA, ISO, ISS]
- regulation of necrotic cell death [ISO]
- regulation of proton-transporting ATPase activity, rotational mechanism [ISO, ISS]
- response to ischemia [ISO, ISS]
- response to oxidative stress [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC25A4
Gene Ontology Biological Process
- aging [IEP]
- apoptotic mitochondrial changes [ISO]
- heart development [IEP]
- liver development [IEP]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of mitochondrial membrane permeability involved in apoptotic process [IDA]
- negative regulation of necroptotic process [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [IDA]
- positive regulation of oxidative phosphorylation uncoupler activity [IMP]
- response to interleukin-1 [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization.
Cyclophilin D (CyPD) is thought to sensitize opening of the mitochondrial permeability transition pore (mPTP) based on the findings that cyclosporin A (CsA), a pseudo-CyPD substrate, hyperpolarizes the mitochondrial membrane potential (DeltaPsi) and inhibits apoptosis. We provide evidence that contrasts with this model. Using live cell imaging and two photon microscopy, we report that overexpression of CyPD desensitizes HEK293 and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID