BAIT

PROSBETA5

Beta-5, CG12323, Dmel\CG12323, LD08717, PSMB5, Pros b5, anon-WO0118547.116, beta5, dbeta5, Dmel_CG12323

Proteasome beta5 subunit

GO Process (6)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

cell proliferation [IMP]

centrosome organization [IMP]

mitotic spindle elongation [IMP]

mitotic spindle organization [IMP]

neurogenesis [IMP]

proteasome-mediated ubiquitin-dependent protein catabolic process [IC]

Gene Ontology Molecular Function

endopeptidase activity [IC, ISS, NAS]

Gene Ontology Cellular Component

proteasome core complex [IDA, ISS]

CRISPR Database FlyBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Drosophila melanogaster

PREY

ESG

4B7, BG:DS07851.7, CG3758, Dmel\CG3758, br43, dgl, flg, l(2)07082, l(2)35Ce, l(2)4B7, l(2)br43, l(2)esg, l35Ce, shof, wiz, Dmel_CG3758

escargot

GO Process (20)

GO Function (3)

GO Component (1)

Gene Ontology Biological Process

asymmetric neuroblast division [IGI]

branch fusion, open tracheal system [IMP, TAS]

cell fate determination [IMP]

cell fate specification [IMP]

central nervous system development [IGI, IMP]

epithelial cell migration, open tracheal system [IMP]

fusion cell fate specification [TAS]

genital disc development [IMP]

germ-line stem cell maintenance [IMP]

gravitaxis [IMP]

maintenance of imaginal histoblast diploidy [IMP]

negative regulation of DNA endoreduplication [IMP]

negative regulation of transcription from RNA polymerase II promoter [IDA]

olfactory behavior [IMP]

open tracheal system development [IMP, NAS, TAS]

peripheral nervous system development [TAS]

positive regulation of transcription from RNA polymerase II promoter [IMP]

regulation of compound eye pigmentation [IMP]

regulation of transcription from RNA polymerase II promoter [ISS]

wing disc development [IMP]

Gene Ontology Molecular Function

DNA binding [IDA, NAS]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
sequence-specific DNA binding transcription factor activity [ISS]

Gene Ontology Cellular Component

nucleus [IDA, ISS, NAS]

CRISPR Database FlyBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Drosophila melanogaster

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A protein interaction map of Drosophila melanogaster.

Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Spriggs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furtak K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley RL, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, Rothberg JM

Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid-based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map of 7048 proteins and 20,405 interactions. A computational method of rating two-hybrid interaction confidence ... [more]

Science Dec. 05, 2003; 302(5651);1727-36 [Pubmed: 14605208]

Throughput

High Throughput

Curated By

BioGRID