ESR1
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- chromatin remodeling [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- intracellular steroid hormone receptor signaling pathway [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipase C activity [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [NAS]
- response to estradiol [IDA]
- response to estrogen [IDA]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
GPER1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- apoptotic chromosome condensation [ISS]
- cellular response to estradiol stimulus [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to mineralocorticoid stimulus [ISS]
- cellular response to peptide hormone stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- cytosolic calcium ion homeostasis [ISS]
- intracellular steroid hormone receptor signaling pathway [IDA]
- mineralocorticoid receptor signaling pathway [ISS]
- negative regulation of DNA metabolic process [ISS]
- negative regulation of cell cycle arrest [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of inflammatory response [IDA]
- negative regulation of leukocyte activation [IDA]
- negative regulation of lipid biosynthetic process [ISS]
- neuronal action potential [ISS]
- nuclear fragmentation involved in apoptotic nuclear change [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of MAPK cascade [ISS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- positive regulation of apoptotic process [ISS]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of endothelial cell apoptotic process [ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [IDA]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inositol trisphosphate biosynthetic process [IDA]
- positive regulation of insulin secretion [ISS]
- positive regulation of neurogenesis [ISS]
- positive regulation of neurotransmitter secretion [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of release of cytochrome c from mitochondria [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of uterine smooth muscle contraction [IDA]
- positive regulation of vasodilation [ISS]
- steroid hormone mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- axon [ISS]
- axon terminus [ISS]
- cytoplasm [ISS]
- cytoplasmic vesicle membrane [IDA]
- dendrite [ISS]
- dendritic shaft [ISS]
- dendritic spine head [ISS]
- dendritic spine membrane [ISS]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- integral component of plasma membrane [TAS]
- intracellular [ISS]
- keratin filament [IDA]
- mitochondrial membrane [ISS]
- neuronal postsynaptic density [ISS]
- nuclear envelope [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- postsynaptic density [ISS]
- presynaptic active zone [ISS]
- presynaptic membrane [ISS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The GPER1/SPOP axis mediates ubiquitination-dependent degradation of ER? to inhibit the growth of breast cancer induced by oestrogen.
G protein-coupled oestrogen receptor 1 (GPER1), predicted to be a novel oestrogen receptor, has been linked to the development and progression of breast cancer. However, the molecular mechanisms underlying its functions remain elusive. Here, we show that the protein levels of GPER1 are negatively associated with those of ER? and that higher expression of GPER1 correlated with a better clinical ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID