BAIT
THRB
Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, c-erbAbeta
thyroid hormone receptor beta
GO Process (19)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI]
- female courtship behavior [IMP]
- intracellular receptor signaling pathway [ISO, TAS]
- negative regulation of female receptivity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of ossification [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cholesterol metabolic process [ISO]
- regulation of heart contraction [IMP]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- regulation of transcription, DNA-templated [TAS]
- regulation of triglyceride metabolic process [ISO]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SLC25A5
Ant2, RP23-286I5.1
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
GO Process (2)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor ?1.
Thyroid hormones (THs) play a critical role in the metabolic phenotype of the heart; and most of the effects involve transcriptional regulation via thyroid hormone receptors (TRs). TRs ability to form combinatorial complexes with an array of partners accounts for TRs physiological flexibility in modulating gene expression. To identify proteins that associate with TR?1 in the heart we performed a ... [more]
Biochem Biophys Res Commun Oct. 22, 2021; 576();15-21 [Pubmed: 34474245]
Throughput
- High Throughput
Additional Notes
- C57BL/6 male mouse - heart tissue
Curated By
- BioGRID