BAIT
THRB
Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, c-erbAbeta
thyroid hormone receptor beta
GO Process (19)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI]
- female courtship behavior [IMP]
- intracellular receptor signaling pathway [ISO, TAS]
- negative regulation of female receptivity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of ossification [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cholesterol metabolic process [ISO]
- regulation of heart contraction [IMP]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- regulation of transcription, DNA-templated [TAS]
- regulation of triglyceride metabolic process [ISO]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FA2H
FAAH, Faxdc1, G630055L08Rik
fatty acid 2-hydroxylase
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- central nervous system myelin maintenance [IMP]
- fatty acid metabolic process [IDA]
- lipid modification [IDA, IMP]
- oxidation-reduction process [IDA]
- peripheral nervous system myelin maintenance [IMP]
- regulation of cell proliferation [IMP]
- regulation of hair cycle [IMP]
- sebaceous gland cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor ?1.
Thyroid hormones (THs) play a critical role in the metabolic phenotype of the heart; and most of the effects involve transcriptional regulation via thyroid hormone receptors (TRs). TRs ability to form combinatorial complexes with an array of partners accounts for TRs physiological flexibility in modulating gene expression. To identify proteins that associate with TR?1 in the heart we performed a ... [more]
Biochem Biophys Res Commun Oct. 22, 2021; 576();15-21 [Pubmed: 34474245]
Throughput
- High Throughput
Additional Notes
- C57BL/6 male mouse - heart tissue
Curated By
- BioGRID