BAIT
THRB
Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, c-erbAbeta
thyroid hormone receptor beta
GO Process (19)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI]
- female courtship behavior [IMP]
- intracellular receptor signaling pathway [ISO, TAS]
- negative regulation of female receptivity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of ossification [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cholesterol metabolic process [ISO]
- regulation of heart contraction [IMP]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- regulation of transcription, DNA-templated [TAS]
- regulation of triglyceride metabolic process [ISO]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NLGN1
6330415N05Rik, BB179718, NL1, Nlg1, mKIAA1070
neuroligin 1
GO Process (38)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA, IMP, ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cytoskeletal matrix organization at active zone [IMP, ISO]
- establishment of protein localization [IMP]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- nervous system development [IDA]
- neurexin clustering [IDA]
- neuron cell-cell adhesion [IDA, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IDA, ISO]
- positive regulation of filopodium assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of synaptic vesicle endocytosis [IMP, ISO]
- positive regulation of synaptic vesicle exocytosis [IMP, ISO]
- postsynaptic density protein 95 clustering [IDA, ISO]
- postsynaptic membrane assembly [IDA]
- presynaptic membrane assembly [IDA, ISO]
- protein heterotetramerization [ISO]
- protein homooligomerization [IDA]
- protein localization to synapse [IDA]
- protein targeting [ISO]
- receptor localization to synapse [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of neuron differentiation [IDA]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- synapse assembly [IDA, ISO]
- synapse organization [IGI, ISO]
- synaptic vesicle clustering [IDA, ISO]
- synaptic vesicle targeting [IMP]
- terminal button organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor ?1.
Thyroid hormones (THs) play a critical role in the metabolic phenotype of the heart; and most of the effects involve transcriptional regulation via thyroid hormone receptors (TRs). TRs ability to form combinatorial complexes with an array of partners accounts for TRs physiological flexibility in modulating gene expression. To identify proteins that associate with TR?1 in the heart we performed a ... [more]
Biochem Biophys Res Commun Oct. 22, 2021; 576();15-21 [Pubmed: 34474245]
Throughput
- High Throughput
Additional Notes
- C57BL/6 male mouse - heart tissue
Curated By
- BioGRID