BAIT
THRB
Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, c-erbAbeta
thyroid hormone receptor beta
GO Process (19)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IGI]
- female courtship behavior [IMP]
- intracellular receptor signaling pathway [ISO, TAS]
- negative regulation of female receptivity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of ossification [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cholesterol metabolic process [ISO]
- regulation of heart contraction [IMP]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- regulation of transcription, DNA-templated [TAS]
- regulation of triglyceride metabolic process [ISO]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SHC1
Shc, ShcA, p66, p66shc
src homology 2 domain-containing transforming protein C1
GO Process (16)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [ISO]
- actin cytoskeleton reorganization [IMP]
- activation of MAPK activity [IMP, ISO]
- aging [ISO]
- angiogenesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA, IDA]
- heart development [IMP]
- insulin receptor signaling pathway [IBA, ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of vasoconstriction [ISO]
- regulation of cell proliferation [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor ?1.
Thyroid hormones (THs) play a critical role in the metabolic phenotype of the heart; and most of the effects involve transcriptional regulation via thyroid hormone receptors (TRs). TRs ability to form combinatorial complexes with an array of partners accounts for TRs physiological flexibility in modulating gene expression. To identify proteins that associate with TR?1 in the heart we performed a ... [more]
Biochem Biophys Res Commun Oct. 22, 2021; 576();15-21 [Pubmed: 34474245]
Throughput
- High Throughput
Additional Notes
- C57BL/6 male mouse - heart tissue
Curated By
- BioGRID