BAIT
OPRM1
LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
opioid receptor, mu 1
GO Process (21)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- behavioral response to ethanol [IMP]
- cellular response to morphine [IBA]
- cellular response to stress [IMP]
- negative regulation of Wnt protein secretion [IMP]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of cAMP-mediated signaling [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of cytosolic calcium ion concentration [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- neuropeptide signaling pathway [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of neurogenesis [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- sensory perception [NAS]
- sensory perception of pain [IBA, ISS]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HGS
HRS
hepatocyte growth factor-regulated tyrosine kinase substrate
GO Process (13)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling.
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is well known to terminate cell signaling by sorting activated receptors to the MVB/lysosomal pathway. Here we identify a distinct role of Hrs in promoting rapid recycling of endocytosed signaling receptors to the plasma membrane. This function of Hrs is specific for receptors that recycle in a sequence-directed manner, in contrast to default ... [more]
EMBO J. Jul. 06, 2005; 24(13);2265-83 [Pubmed: 15944737]
Throughput
- Low Throughput
Curated By
- BioGRID