PPP1R3C
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKAA2
Gene Ontology Biological Process
- cellular response to glucose starvation [IDA]
- cellular response to nutrient levels [IDA]
- cellular response to prostaglandin E stimulus [IGI]
- fatty acid homeostasis [ISO]
- glucose homeostasis [IMP]
- histone-serine phosphorylation [IDA]
- lipid biosynthetic process [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of apoptotic process [IMP]
- positive regulation of autophagy [IMP]
- positive regulation of glycolytic process [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of circadian rhythm [IMP]
- regulation of energy homeostasis [ISO]
- regulation of lipid metabolic process [ISO]
- response to activity [ISO]
- response to caffeine [ISO]
- response to stress [IMP]
Gene Ontology Molecular Function- AMP-activated protein kinase activity [IDA, IMP, ISO, TAS]
- ATP binding [ISO]
- chromatin binding [IDA]
- histone serine kinase activity [IDA]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [IMP, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
- AMP-activated protein kinase activity [IDA, IMP, ISO, TAS]
- ATP binding [ISO]
- chromatin binding [IDA]
- histone serine kinase activity [IDA]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [IMP, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.
R5/PTG is one of the glycogen targeting subunits of type 1 protein phosphatase, a master regulator of glycogen synthesis. R5/PTG recruits the phosphatase to the places where glycogen synthesis occurs, allowing the activation of glycogen synthase and the inactivation of glycogen phosphorylase, thus increasing glycogen synthesis and decreasing its degradation. In this report, we show that the activity of R5/PTG ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID