CDH1
Gene Ontology Biological Process
- adherens junction organization [IMP, TAS]
- apoptotic process [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to lithium ion [IDA]
- establishment of protein localization to plasma membrane [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [NAS]
- negative regulation of cell-cell adhesion [IMP]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to plasma membrane [IDA]
- regulation of immune response [TAS]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- aggresome [IDA]
- apical junction complex [IDA]
- catenin complex [IDA]
- cell junction [IDA, TAS]
- cell-cell adherens junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lateral plasma membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network [IMP]
CDK5R1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- brain development [ISS, NAS]
- cell proliferation [TAS]
- ephrin receptor signaling pathway [ISS]
- ionotropic glutamate receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- neuron cell-cell adhesion [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neuron projection development [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of neuron differentiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- contractile fiber [ISS]
- cytoplasm [ISS]
- cytosol [TAS]
- dendrite [ISS]
- dendritic spine [ISS]
- growth cone [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISS]
- neuromuscular junction [ISS]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [ISS]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes.
CDK5 is a member of proline-directed serine/threonine kinases. Although its cDNA was originally cloned as a homologue to those for the other members of the cyclin-dependent kinase (CDK) family, CDK5 has been shown to function differently from other CDKs. CDK5 is activated by non-cyclin partners, p35 and p39, and important during brain development by influencing adhesion, migration and differentiation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDK5R1 CDH1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID