BAIT

ESR1

ER, ESR, ESRA, ESTRR, Era, NR3A1, RP1-130E4.1
estrogen receptor 1
GO Process (22)
GO Function (16)
GO Component (6)
Homo sapiens
PREY

C1QBP

GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
complement component 1, q subcomponent binding protein
GO Process (21)
GO Function (9)
GO Component (7)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ER? glycosylation and stability to cancer.

Shin EM, Huynh VT, Neja SA, Liu CY, Raju A, Tan K, Tan NS, Gunaratne J, Bi X, Iyer LM, Aravind L, Tergaonkar V

What covalent modifications control the temporal ubiquitination of ER? and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ER?-inducible enzyme, catalyzes O-GlcNAcylation of ER? at residues T553/S554, which stabilizes ER? protein by inhibiting association with the ubiquitin ligase ZNF598. Loss of GREB1-mediated glycosylation of ER? results in reduced cellular ER? levels and insensitivity ... [more]

Sci Adv Mar. 01, 2021; 7(12); [Pubmed: 33731348]

Throughput

  • High Throughput

Curated By

  • BioGRID