An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.

Zhang W, Wang Q, Yang F, Zhu Z, Duan Y, Yang Y, Cao W, Zhang K, Ma J, Liu X, Zheng H

The negative regulation of antiviral immune responses is essential for the host to maintain homeostasis. Jumonji domain-containing protein 6 (JMJD6) was previously identified with a number of functions during RNA virus infection. Upon viral RNA recognition, retinoic acid-inducible gene-I-like receptors (RLRs) physically interact with the mitochondrial antiviral signaling protein (MAVS) and activate TANK-binding kinase 1 (TBK1) to induce type-I interferon ... [more]

PLoS Pathog Dec. 01, 2020; 17(3);e1009366 [Pubmed: 33684176]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

JMJD6

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [TAS]histone demethylase activity (H3-R2 specific) [IDA]histone demethylase activity (H4-R3 specific) [IDA]identical protein binding [IDA, IPI]iron ion binding [IDA]peptidyl-lysine 5-dioxygenase activity [IDA]protein binding [IPI]single-stranded RNA binding [IDA]

Gene Ontology Cellular Component

HSPH1