BAIT
CNTNAP2
5430425M22Rik, Caspr2, mKIAA0868
contactin associated protein-like 2
GO Process (10)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adult behavior [ISO]
- cell adhesion [TAS]
- cellular protein localization [IMP]
- clustering of voltage-gated potassium channels [IMP]
- learning [ISO]
- neuron projection development [IGI]
- neuron recognition [TAS]
- protein localization to juxtaparanode region of axon [IMP]
- social behavior [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAP2
G1-397-34, MAP-2, Mtap-2, Mtap2, repro4, AC091465.1
microtubule-associated protein 2
GO Process (4)
GO Function (4)
GO Component (16)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- CA3 pyramidal cell dendrite [IDA]
- cell body [IDA]
- cytoplasm [IDA, ISO]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- intracellular [IDA]
- microtubule associated complex [TAS]
- neuron projection [IDA, ISO]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear periphery [IDA]
- nucleolus [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the specific functional roles that Caspr2 plays in the central nervous system and their underlying mechanisms remain incompletely understood. Here, we report on a functional role for Caspr2 in the developing cerebellum. Using a combination of confocal microscopy, biochemical analyses, and behavioral testing, ... [more]
J Biol Chem Dec. 04, 2019; 295(36);12716-12726 [Pubmed: 32675284]
Throughput
- Low Throughput
Curated By
- BioGRID