CNTNAP2
Gene Ontology Biological Process
- adult behavior [ISO]
- cell adhesion [TAS]
- cellular protein localization [IMP]
- clustering of voltage-gated potassium channels [IMP]
- learning [ISO]
- neuron projection development [IGI]
- neuron recognition [TAS]
- protein localization to juxtaparanode region of axon [IMP]
- social behavior [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITPR1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA]
- cellular response to cAMP [ISO]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- inositol phosphate-mediated signaling [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- negative regulation of calcium-mediated signaling [ISO]
- negative regulation of neuron death [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- post-embryonic development [IMP]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- response to hypoxia [IDA, ISO]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, TAS]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, TAS]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
- calcineurin complex [IDA]
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IMP]
- dendrite [ISO]
- endoplasmic reticulum [IGI, TAS]
- endoplasmic reticulum membrane [IDA, ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane raft [ISO]
- neuronal cell body [ISO]
- nuclear envelope [IDA, ISO]
- nuclear inner membrane [IDA]
- nucleolus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- platelet dense granule membrane [ISO]
- platelet dense tubular network [ISO]
- postsynaptic density [IDA, ISO]
- protein complex [IPI, ISO]
- sarcoplasmic reticulum [IDA, ISO]
- secretory granule membrane [ISO]
- synaptic membrane [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the specific functional roles that Caspr2 plays in the central nervous system and their underlying mechanisms remain incompletely understood. Here, we report on a functional role for Caspr2 in the developing cerebellum. Using a combination of confocal microscopy, biochemical analyses, and behavioral testing, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CNTNAP2 ITPR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID