SP1
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- positive regulation by host of viral transcription [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [IDA]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [ISS]
- bHLH transcription factor binding [ISS]
- core promoter sequence-specific DNA binding [ISS]
- double-stranded DNA binding [IDA]
- histone deacetylase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [ISS]
- bHLH transcription factor binding [ISS]
- core promoter sequence-specific DNA binding [ISS]
- double-stranded DNA binding [IDA]
- histone deacetylase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [IC]
KAT2B
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [IDA]
- Notch signaling pathway [TAS]
- cell cycle arrest [TAS]
- cellular response to insulin stimulus [IDA]
- chromatin organization [TAS]
- chromatin remodeling [IDA, NAS]
- gene expression [TAS]
- histone H3 acetylation [IDA]
- internal peptidyl-lysine acetylation [IDA]
- negative regulation of cell proliferation [IDA]
- peptidyl-lysine acetylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein acetylation [TAS]
- regulation of protein ADP-ribosylation [IDA]
- transcription from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- acetyltransferase activity [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [ISS]
- histone acetyltransferase activity [IDA]
- histone deacetylase binding [IPI]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISS]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IPI]
- transcription factor binding [IPI]
- acetyltransferase activity [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [ISS]
- histone acetyltransferase activity [IDA]
- histone deacetylase binding [IPI]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISS]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of ERK1 gene expression by coactivator proteins.
RARs (retinoic acid receptors) mediate the effect of their ligand RA (retinoic acid) on gene expression. We previously showed that RA inhibited cellular proliferation in part by decreasing expression of the mitogen activated protein kinase ERK1 (extracellular signal regulated kinase 1). However, the mechanism by which RA regulates ERK1 expression is largely uncharacterized. The present study characterizes coactivator-mediated regulation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SP1 KAT2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SP1 KAT2B | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID