BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GLUL
GS, Glns
glutamate-ammonia ligase (glutamine synthetase)
GO Process (10)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
- ammonia assimilation cycle [ISO]
- cell proliferation [ISO]
- cellular response to starvation [IEP]
- glutamate metabolic process [ISO]
- glutamine biosynthetic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein homooligomerization [ISO]
- response to glucose [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon terminus [ISO]
- cell body [IDA]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- glial cell projection [IDA]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [IDA]
- myelin sheath [IDA]
- neuron projection [ISO]
- nucleus [ISO]
- perikaryon [ISO]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
J Biol Chem Dec. 09, 2017; 293(10);3710-3719 [Pubmed: 29382714]
Throughput
- High Throughput
Curated By
- BioGRID