MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOD1
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- aging [IMP]
- anterograde axon cargo transport [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cell aging [ISO]
- cellular iron ion homeostasis [IMP]
- embryo implantation [IMP]
- glutathione metabolic process [IMP]
- heart contraction [IMP, ISO]
- hydrogen peroxide biosynthetic process [IMP, ISO]
- locomotory behavior [IMP]
- muscle cell cellular homeostasis [IMP]
- myeloid cell homeostasis [IGI, IMP]
- negative regulation of apoptotic process [IDA, IMP, ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neurofilament cytoskeleton organization [IGI, IMP]
- ovarian follicle development [IMP]
- oxidation-reduction process [IMP]
- peripheral nervous system myelin maintenance [IMP]
- positive regulation of catalytic activity [ISO]
- positive regulation of cytokine production [ISO]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of Rac GTPase activity [ISO]
- regulation of blood pressure [IMP]
- regulation of mitochondrial membrane potential [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein kinase activity [ISO]
- relaxation of vascular smooth muscle [IMP]
- removal of superoxide radicals [IDA, IGI, IMP, ISO, TAS]
- response to axon injury [IMP]
- response to copper ion [ISO]
- response to drug [IMP]
- response to ethanol [IMP]
- response to heat [IMP]
- response to hydrogen peroxide [IMP]
- response to nutrient levels [ISO]
- response to organic substance [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- retina homeostasis [IMP]
- retrograde axon cargo transport [IMP]
- sensory perception of sound [IMP]
- spermatogenesis [IMP]
- superoxide anion generation [IDA]
- superoxide metabolic process [IMP, ISO]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IMP]
- cytoplasm [ISO, TAS]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite cytoplasm [ISO]
- dense core granule [ISO]
- extracellular matrix [ISO]
- extracellular region [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- peroxisome [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- secretory granule [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
Throughput
- High Throughput
Curated By
- BioGRID