MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STXBP1
Gene Ontology Biological Process
- axon target recognition [IMP]
- exocytosis [IMP]
- long term synaptic depression [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of synaptic transmission, GABAergic [IDA]
- neuromuscular synaptic transmission [IMP]
- neurotransmitter secretion [IMP]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of exocytosis [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [ISO]
- regulation of synaptic vesicle priming [ISO]
- synaptic vesicle maturation [IMP]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
Throughput
- High Throughput
Curated By
- BioGRID