BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRDX5
AOEB166, AOPP, Pmp20, Prdx6, PrxV
peroxiredoxin 5
GO Process (11)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- NADPH oxidation [ISO]
- cellular response to reactive oxygen species [ISO]
- hydrogen peroxide catabolic process [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of oxidoreductase activity [ISO]
- negative regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of collagen biosynthetic process [ISO]
- reactive nitrogen species metabolic process [ISO]
- regulation of apoptosis involved in tissue homeostasis [ISO]
- response to oxidative stress [ISO, ISS]
Gene Ontology Molecular Function- RNA polymerase III regulatory region DNA binding [ISO]
- antioxidant activity [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- peroxidase activity [ISO]
- peroxiredoxin activity [ISO]
- peroxynitrite reductase activity [ISO]
- protein dimerization activity [ISO]
- receptor binding [ISO, ISS]
- RNA polymerase III regulatory region DNA binding [ISO]
- antioxidant activity [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- peroxidase activity [ISO]
- peroxiredoxin activity [ISO]
- peroxynitrite reductase activity [ISO]
- protein dimerization activity [ISO]
- receptor binding [ISO, ISS]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
J Biol Chem Dec. 09, 2017; 293(10);3710-3719 [Pubmed: 29382714]
Throughput
- High Throughput
Curated By
- BioGRID