MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB10
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi to plasma membrane transport [ISO]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [ISO]
- axonogenesis [ISO]
- cellular response to insulin stimulus [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- endosomal transport [ISO]
- establishment of neuroblast polarity [ISO]
- establishment of protein localization to endoplasmic reticulum membrane [ISO]
- establishment of protein localization to membrane [ISO]
- intracellular protein transport [TAS]
- protein localization to plasma membrane [IMP]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- cell [TAS]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum tubular network [ISO]
- endosome [ISO]
- endosome membrane [IBA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- insulin-responsive compartment [IBA, ISO]
- intracellular [TAS]
- membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- primary cilium [IDA, ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
Throughput
- High Throughput
Curated By
- BioGRID