BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP3R1
CaNB1, Cnb1, MCIP1, RP23-32H19.1
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
GO Process (12)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- NFAT protein import into nucleus [IMP]
- Schwann cell development [IMP]
- calcineurin-NFAT signaling cascade [IGI, ISO]
- epithelial to mesenchymal transition [IMP]
- heart development [IMP]
- lung epithelial cell differentiation [IMP]
- myelination in peripheral nervous system [IMP]
- patterning of blood vessels [IMP]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IMP, ISO]
- protein localization to nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
J Biol Chem Dec. 09, 2017; 293(10);3710-3719 [Pubmed: 29382714]
Throughput
- High Throughput
Curated By
- BioGRID