BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SYT1
AW124717, G630098F17Rik, SytI
synaptotagmin I
GO Process (9)
GO Function (15)
GO Component (13)
Gene Ontology Biological Process
- detection of calcium ion [ISO]
- neurotransmitter secretion [IDA]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of calcium ion-dependent exocytosis [ISO]
- regulation of regulated secretory pathway [ISO]
- response to calcium ion [ISO]
- synaptic vesicle exocytosis [IMP]
- vesicle docking [ISO]
Gene Ontology Molecular Function- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dense core granule [ISO]
- excitatory synapse [ISO]
- intracellular organelle [ISO]
- neuron projection [IDA]
- plasma membrane [ISO, TAS]
- presynaptic membrane [IDA]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO, TAS]
- synaptic vesicle membrane [IDA]
- terminal bouton [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
J Biol Chem Dec. 09, 2017; 293(10);3710-3719 [Pubmed: 29382714]
Throughput
- High Throughput
Curated By
- BioGRID