BAIT
MAPT
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
GO Process (8)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MT3
Mt-3
metallothionein 3
GO Process (26)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- astrocyte development [IDA]
- cadmium ion homeostasis [IMP]
- cellular lipid catabolic process [IMP]
- cellular metal ion homeostasis [IDA]
- cellular response to oxidative stress [IDA]
- cellular zinc ion homeostasis [IDA, IMP]
- cholesterol catabolic process [IMP]
- energy reserve metabolic process [IMP]
- leptin-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of autophagy [IMP]
- negative regulation of necrotic cell death [IMP]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell death [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of lysosomal membrane permeability [IMP]
- positive regulation of oxygen metabolic process [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of protein glycosylation [IMP]
- regulation of response to food [IMP]
- response to oxidative stress [IMP]
- zinc ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An N-terminal motif unique to primate tau enables differential protein-protein interactions.
Compared with other mammalian species, humans are particularly susceptible to tau-mediated neurodegenerative disorders. Differential interactions of the tau protein with other proteins are critical for mediating tau's physiological functions as well as tau-associated pathological processes. Primate tau harbors an 11-amino acid-long motif in its N-terminal region (residues 18-28), which is not present in non-primate species and whose function is unknown. ... [more]
J Biol Chem Dec. 09, 2017; 293(10);3710-3719 [Pubmed: 29382714]
Throughput
- High Throughput
Curated By
- BioGRID