BAIT
RAPSN
RAPSYN, RNF205
receptor-associated protein of the synapse
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHRNA4
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal)
GO Process (21)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- B cell activation [ISS]
- DNA repair [IMP]
- action potential [ISS]
- behavioral response to nicotine [IMP]
- calcium ion transport [ISS]
- cation transmembrane transport [IDA, TAS]
- cognition [IMP]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- membrane depolarization [ISS]
- neurological system process [IMP]
- regulation of dopamine secretion [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- sensory perception of pain [ISS]
- signal transduction [IDA]
- synaptic transmission [NAS, TAS]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactions of the rapsyn RING-H2 domain with dystroglycan.
Rapsyn, a peripheral membrane protein of skeletal muscle, is necessary for the formation of the highly organized structure of the vertebrate neuromuscular junction. For mice lacking rapsyn, there is a failure of postsynaptic specialization characterized by an absence of nicotinic acetylcholine receptors (nAChRs) and other integral and peripheral membrane proteins such as beta-dystroglycan and utrophin. Dystroglycan is necessary for the ... [more]
J. Biol. Chem. Jul. 06, 2001; 276(27);24911-7 [Pubmed: 11342559]
Throughput
- Low Throughput
Additional Notes
- assayed using a modified yeast two-hybrid assay examining interaction at the cell membrane
Curated By
- BioGRID