SHC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TEK
Gene Ontology Biological Process
- Tie signaling pathway [IDA]
- angiogenesis [ISS]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- definitive hemopoiesis [TAS]
- endothelial cell proliferation [ISS]
- heart development [ISS]
- heart trabecula formation [ISS]
- leukocyte migration [TAS]
- negative regulation of angiogenesis [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of endothelial cell apoptotic process [ISS]
- negative regulation of inflammatory response [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of actin cytoskeleton reorganization [IMP]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of endothelial cell migration [IDA, IMP]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IDA, IMP]
- positive regulation of protein phosphorylation [IDA, IMP]
- protein autophosphorylation [IDA]
- protein oligomerization [IDA]
- regulation of endothelial cell apoptotic process [TAS]
- regulation of establishment or maintenance of cell polarity [IMP]
- regulation of vascular permeability [TAS]
- signal transduction [TAS]
- sprouting angiogenesis [IMP]
- substrate adhesion-dependent cell spreading [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion.
Gliomas are characterized by diffuse infiltration of tumor cells into surrounding brain tissue, and this highly invasive nature contributes to disease recurrence and poor patient outcomes. The molecular mechanisms underlying glioma cell invasion remain incompletely understood, limiting development of new targeted therapies. Here, we have identified phosphotyrosine adaptor protein ShcD as upregulated in malignant glioma and shown that it associates ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TEK SHC4 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 3201134 |
Curated By
- BioGRID