TRPC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRM1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS]
- G-protein coupled receptor signaling pathway [ISO, ISS]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- calcium-mediated signaling [IDA]
- cellular response to electrical stimulus [ISO]
- dimeric G-protein coupled receptor signaling pathway [ISO, ISS]
- locomotory behavior [ISO]
- membrane depolarization [TAS]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO, ISS, TAS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of MAPK cascade [ISO]
- regulation of glutamate secretion [TAS]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic transmission, glutamatergic [IDA]
- sensory perception of pain [IEP, ISO]
- synaptic transmission [IEP]
- synaptic transmission, GABAergic [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.
Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells and express a Hebbian form of long-term potentiation (LTP) at their excitatory input synapses. This LTP requires the activation of metabotropic glutamate receptors 1a (mGluR1a) and Ca2+ entry via transient receptor potential (TRP) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID