BAIT
SRI
CP-22, CP22, SCN, V19
sorcin
GO Process (17)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- action potential [TAS]
- intracellular sequestering of iron ion [TAS]
- muscle organ development [TAS]
- negative regulation of heart rate [IMP]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- proteolysis [IBA]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cell communication by electrical coupling [TAS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IMP]
- regulation of heart contraction [TAS]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of relaxation of muscle [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of striated muscle contraction [TAS]
- signal transduction [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RYR3
RYR-3
ryanodine receptor 3
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISS]
- calcium ion transport [IMP]
- cellular response to ATP [ISS]
- cellular response to caffeine [ISS]
- cellular response to calcium ion [ISS]
- cellular response to magnesium ion [ISS]
- ion transmembrane transport [TAS]
- protein homotetramerization [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.
Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), and targeting this process may be therapeutically beneficial. Under this perspective, it is important to study proteins that regulate calcium homeostasis in the cell. Sorcin is one of the most expressed calcium-binding ... [more]
Cell Death Dis Dec. 15, 2019; 11(10);861 [Pubmed: 33060591]
Throughput
- Low Throughput
Curated By
- BioGRID