BAIT
KCNA2
HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, RP11-284N8.1
potassium voltage-gated channel, shaker-related subfamily, member 2
GO Process (6)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KCNA2
HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, RP11-284N8.1
potassium voltage-gated channel, shaker-related subfamily, member 2
GO Process (6)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function.
Episodic ataxia type-1 syndrome (EA-1) is an autosomal dominant neurological disorder that manifests itself during infancy and results from point mutations in the voltage-gated potassium channel gene hKv1.1. The hallmark of the disease is continuous myokymia and episodic attacks of spastic contractions of the skeletal muscles, which cause permanent disability. Coexpression of hKv1.1 and hKv1.2 subunits produces heteromeric potassium channels ... [more]
FASEB J. Aug. 01, 1999; 13(11);1335-45 [Pubmed: 10428758]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
KCNA2 KCNA2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID