RC3H1
Gene Ontology Biological Process
- cytoplasmic mRNA processing body assembly [ISS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of T-helper cell differentiation [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of germinal center formation [ISS]
- nuclear-transcribed mRNA catabolic process [ISS]
- posttranscriptional regulation of gene expression [ISS]
- protein ubiquitination [TAS]
- regulation of T cell receptor signaling pathway [ISS]
- regulation of germinal center formation [ISS]
- regulation of mRNA stability [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RBMX
Gene Ontology Biological Process
- RNA splicing [TAS]
- cellular response to interleukin-1 [IDA]
- gene expression [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- membrane protein ectodomain proteolysis [IDA]
- negative regulation of mRNA splicing, via spliceosome [ISS]
- osteoblast differentiation [IDA]
- positive regulation of mRNA splicing, via spliceosome [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein homooligomerization [ISS]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals. The degradation of TNF-α mRNA is critical for restricting TNF-α synthesis and involves a constitutive decay element (CDE) in the 3' UTR of the mRNA. Here, we demonstrate that the CDE folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin ... [more]
Throughput
- High Throughput
Additional Notes
- it is not clear from the article whether Roquin or Roquin2 was the bait
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RC3H1 RBMX | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID