BAIT
RC3H2
MNAB, RNF164, RP11-163B6.3
ring finger and CCCH-type domains 2
GO Process (1)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSD17B4
DBP, MFE-2, MPF-2, PRLTS1, SDR8C1
hydroxysteroid (17-beta) dehydrogenase 4
GO Process (15)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- alpha-linolenic acid metabolic process [TAS]
- androgen metabolic process [IDA]
- bile acid biosynthetic process [TAS]
- bile acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- estrogen metabolic process [IDA]
- fatty acid beta-oxidation [IDA]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- medium-chain fatty-acyl-CoA metabolic process [IDA]
- metabolic process [IDA]
- osteoblast differentiation [IDA]
- oxidation-reduction process [IDA, IMP]
- small molecule metabolic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
- very long-chain fatty-acyl-CoA metabolic process [IDA]
Gene Ontology Molecular Function- 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [IDA]
- 3-hydroxyacyl-CoA dehydrogenase activity [IDA, IMP, TAS]
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity [TAS]
- long-chain-enoyl-CoA hydratase activity [IDA, TAS]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [IDA]
- 3-hydroxyacyl-CoA dehydrogenase activity [IDA, IMP, TAS]
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity [TAS]
- long-chain-enoyl-CoA hydratase activity [IDA, TAS]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals. The degradation of TNF-α mRNA is critical for restricting TNF-α synthesis and involves a constitutive decay element (CDE) in the 3' UTR of the mRNA. Here, we demonstrate that the CDE folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin ... [more]
Cell May. 09, 2013; 153(4);869-81 [Pubmed: 23663784]
Throughput
- High Throughput
Additional Notes
- it is not clear from the article whether Roquin or Roquin2 was the bait
Curated By
- BioGRID