FLT1
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cell migration [IMP]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- embryonic morphogenesis [ISS]
- monocyte chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phospholipase C activity [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein autophosphorylation [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor receptor-1 signaling pathway [IDA]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
Gene Ontology Cellular Component
PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
Deciphering the network of signaling pathways in cancer via protein-protein interactions (PPIs) at the cellular level is a promising approach but remains incomplete. We used an in situ proximity ligation assay to identify and quantify 67 endogenous PPIs among 21 interlinked pathways in two hepatocellular carcinoma (HCC) cells, Huh7 (minimally migratory cells) and Mahlavu (highly migratory cells). We then applied ... [more]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLT1 PTPN11 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 1505058 |
Curated By
- BioGRID